Large assembly efficiency

I know of some companies using CREO are building large assemblies of entire cars or trucks, or larger.

How does CREO fare with such assemblies? What's a good setup to making CREO more efficient? What options would I need to set to improve opening larger assembly structures in CREO?

When I say more efficient, I'm referring to opening a large assembly and it's duration; does CREO lag when adding or removing features?

Thanks,

Jason